SCHEMBL11277818

SCHEMBL11277818

Cc1c(N)c(C(=O)O)n(C)c1C

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.44
GPR35 Q9HC97 1/20 0.40
KMT2A Q03164 2/20 0.35
GRIA2 P42262 1/20 0.35
GRIA4 P48058 1/20 0.35
GAA P10253 1/20 0.32
MYC P01106 1/20 0.32
KDM4E B2RXH2 2/20 0.31
MEN1 O00255 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Potassium Ion SCHEMBL10967139 0.79 KMT2A (0.33) USP2KMT2A
SCHEMBL3229069 0.76 GPR35 (0.36) USP2GPR35KMT2AMEN1
SCHEMBL11284808 0.75 KMT2A (0.62) USP2KMT2AGAAKDM4E
SCHEMBL20519235 0.70 USP2 (0.49) USP2GPR35KMT2AGRIA2GRIA4
SCHEMBL4813653 0.68 USP2 (0.61) USP2GPR35KMT2AGRIA2GRIA4
SCHEMBL23264663 0.67 USP2 (0.46) USP2GPR35KMT2AGRIA2GRIA4
SCHEMBL28895524 0.67 USP2 (0.54) USP2GPR35KMT2AGRIA2GRIA4
SCHEMBL29727736 0.65 USP2 (0.45) USP2GPR35KMT2AGRIA2GRIA4
SCHEMBL16731958 0.65 USP2 (0.44) USP2GPR35KMT2AKDM4EMEN1
SCHEMBL15959641 0.65 KMT2A (0.38) USP2GPR35KMT2AKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4363816-A TREATMENT OF GASTROINTESTINAL DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1982-12-14 US disclosed