SCHEMBL11277902

SCHEMBL11277902

COC(=O)COc1ccc(Br)cc1C(C)=O

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 5/20 0.73
LMNA P02545 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
HTT P42858 2/20 0.45
ALDH1A1 P00352 3/20 0.45
MAPT P10636 3/20 0.45
TSHR P16473 2/20 0.45
GFER P55789 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
HPGD P15428 1/20 0.44
POLB P06746 1/20 0.43
LRRK2 Q5S007 1/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32678019 1.00 PTGDR2 (0.73) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL32678021 1.00 PTGDR2 (0.73) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL1530945 0.88 PTGDR2 (0.56) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL1997089 0.85 PTGDR2 (0.69) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL789387 0.84 PTGDR2 (1.00) PTGDR2TSHRPOLB
SCHEMBL11263623 0.83 KDM4E (0.53) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL22688831 0.83 PTGDR2 (0.75) PTGDR2SMN1; SMN2ALDH1A1TSHRHPGD
SCHEMBL5519643 0.83 PTGDR2 (0.50) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL11280545 0.82 HTT (0.51) PTGDR2LMNASMN1; SMN2HTTALDH1A1
SCHEMBL11274293 0.82 ALDH1A1 (0.55) PTGDR2LMNASMN1; SMN2HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4320061-A ANTISPASMODIC AGENTS KALI-CHEMIE PHARMA GMBH (DE) 1982-03-16 US disclosed
US-4279905-A GASTROINTESTINAL DISORDERS KALI-CHEMIE PHARMA GMBH (DE) 1981-07-21 US disclosed