Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141328 | 0.91 | PLG (0.50) | PLGPLATLMNAANPEPENPEP | |
| Trifluoroacetic Acid SCHEMBL7418767 | 0.75 | PLG (0.43) | PLGPLATLMNAANPEPENPEP | |
| Trifluoroacetic Acid SCHEMBL939948 | 0.75 | PLG (0.43) | PLGPLATLMNAANPEPENPEP | |
| Trifluoroacetic Acid SCHEMBL6256275 | 0.73 | LMNA (0.46) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL13044796 | 0.65 | PLG (0.60) | PLGPLATLMNAANPEPENPEP | |
| Trifluoroacetic Acid SCHEMBL5722383 | 0.65 | TSHR (0.42) | PLGPLATLMNA | |
| SCHEMBL8595703 | 0.65 | KMT2A (0.46) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL8596354 | 0.65 | KMT2A (0.46) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL11664391 | 0.65 | LMNA (0.65) | PLGPLATLMNAANPEPENPEP | |
| SCHEMBL851113 | 0.64 | LMNA (0.54) | PLGPLATLMNAANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283022-A1 | FURO Ý3, 2-B¨PYRR0L-3-0NES AS CATHEPSIN S INHIBITORS | Amura Therapeutics Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009112826-A1 | FURO [3, 2-B] PYRR0L-3-0NES AS CATHEPSIN S INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |