Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL591922 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28893179 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28363045 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL288699 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL10955970 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL2497150 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL7151962 | 1.00 | — | — | |
| Bicarbonate SCHEMBL20586919 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL9435869 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL17023327 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433077-A | Preparation of 11-bromo-undecylic acid from 10-undecylenic acid and preparation method thereof | 中国五环工程有限公司 | 2022-12-06 | — | — | CN | claimed |
| EP-4318680-A1 | NEGATIVE ELECTRODE PLATE AND PREPARATION METHOD THEREFOR, SECONDARY BATTERY, BATTERY MODULE, BATTERY PACK AND ELECTRIC DEVICE | Contemporary Amperex Technology Co., Limited (CN) | 2024-02-07 | — | — | EP | disclosed |
| CN-115433077-A | Preparation of 11-bromo-undecylic acid from 10-undecylenic acid and preparation method thereof | 中国五环工程有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-110651383-B | Separator without separator substrate and electrochemical device comprising same | 株式会社LG新能源 | 2022-11-29 | — | — | CN | disclosed |
| CN-112898714-A | Preparation and application of multifunctional efficient PVC modified processing aid | 广东鑫达新材料科技有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-111819218-A | Prepreg, laminate, multilayer printed wiring board, semiconductor package, resin composition, and methods for producing prepreg, laminate, and multilayer printed wiring board | 日立化成株式会社 | 2020-10-23 | — | — | CN | disclosed |
| US-9669243-B2 | Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate | BASF SE (DE) | 2017-06-06 | — | — | US | disclosed |
| EP-2109441-B1 | POLYSILOXANE BLOCK COPOLYMERS | BASF SE (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8378038-B2 | Polysiloxane block copolymers | BASF SE (DE) | 2013-02-19 | — | — | US | disclosed |
| CN-101616658-B | Polysiloxane block copolymers | CIBA HOLDING INC CH | 2012-11-14 | — | — | CN | disclosed |
| US-20080199418-A1 | Polysiloxane block copolymers | BASF SE (DE) | 2008-08-21 | — | — | US | disclosed |
| WO-2008095822-A2 | POLYSILOXANE BLOCK COPOLYMERS | CIBA HOLDING INC. (CH) | 2008-08-14 | — | — | WO | disclosed |
| US-20080033106-A1 | Composition for improving wettability of surfaces | CIBA SPECIALTY CHEMICALS CORP. | 2008-02-07 | — | — | US | disclosed |
| WO-2008015136-A1 | BLOCK COPOLYMERS OF DIALLYLDIALKYLAMMONIUM DERIVATIVES | CIBA HOLDING INC. (CH) | 2008-02-07 | — | — | WO | disclosed |
| US-20080033115-A1 | Block copolymers of diallyldialkylammonium derivatives | CIBA SPECIALTY CHEMICALS CORP. | 2008-02-07 | — | — | US | disclosed |
| WO-2008015138-A2 | COMPOSITION FOR IMPROVING WETTABILITY OF SURFACES | CIBA HOLDING INC. (CH) | 2008-02-07 | — | — | WO | disclosed |
| US-7067587-B2 | Polyolefin macromonomer, graft polymer obtained from the polyolefin macromonomer, and use thereof | MITSUI CHEMICALS, INC. (JP) | 2006-06-27 | — | — | US | disclosed |
| US-20040242791-A1 | Polyolefin macromonomer, graft polymer obtained from the polyolefin macromonomer, and use thereof | MITSUI CHEMICALS, INC. (JP) | 2004-12-02 | — | — | US | disclosed |
| EP-1396504-A2 | Polyolefin macromonomer, graft polymer obtained from the polyolefin macromonomer, and use thereof | Mitsui Chemicals, Inc. (JP) | 2004-03-10 | — | — | EP | disclosed |
| CN-1107649-A | Plexiglass specimen embedding method and its formula | DUAN YONGFU (CN) | 1995-09-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080199418-A1 | Polysiloxane block copolymers | KRT18, PUF60, SCNN1B | FFAR3 2104/4885CA1 1573/4885CA2 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.