Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL591922 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL1127897 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28893179 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28363045 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL10955970 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL2497150 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL7151962 | 1.00 | — | — | |
| Bicarbonate SCHEMBL20586919 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL9435869 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL17023327 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 251 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688908-A2 | CROSSLINKED POLYESTER ELASTOMERS, COMPOSITIONS, AND METHODS OF PREPARATION THEREOF | Momentive Performance Materials Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4516824-B1 | POLYMER ELECTROLYTE PREPOLYMERIZATION SOLUTION, POLYMER ELECTROLYTE AND ELECTROCHEMICAL DEVICE | SHENZHEN BTR NEW ENERGY TECH RESEARCH INSTITUTE CO LTD (CN) | 2025-12-10 | — | — | EP | claimed |
| US-12476279-B2 | Oligomer solution of polymer electrolyte, polymer electrolyte and electrochemical device | SHENZHEN BTR NEW ENERGY TECHNOLOGY RESEARCH INSTITUTE CO., LTD. (CN) | 2025-11-18 | — | — | US | claimed |
| CN-119775559-A | Polyimide film and preparation method thereof | 宁波博雅聚力新材料科技有限公司 | 2025-04-08 | — | — | CN | claimed |
| WO-2025071268-A1 | POLYESTER RESIN HAVING EXCELLENT MECHANICAL PROPERTIES AND BIODEGRADABILITY, AND PREPARATION METHOD THEREFOR | 주식회사 삼양사 | 2025-04-03 | — | — | WO | claimed |
| EP-4516824-A1 | POLYMER ELECTROLYTE PREPOLYMERIZATION SOLUTION, POLYMER ELECTROLYTE AND ELECTROCHEMICAL DEVICE | Shenzhen BTR New Energy Technology Research Institute Co., Ltd. (CN) | 2025-03-05 | — | — | EP | claimed |
| US-12234234-B2 | Method for synthesizing 1,7-naphthyridine derivatives | CHENGDA PHARMACEUTICALS CO., LTD. (CN) | 2025-02-25 | — | — | US | claimed |
| CN-116375706-B | Abamectin sodium key intermediate and preparation method thereof | 时森海(杭州)医药科技有限公司 | 2025-02-14 | — | — | CN | claimed |
| US-20250023097-A1 | OLIGOMER SOLUTION OF POLYMER ELECTROLYTE, POLYMER ELECTROLYTE AND ELECTROCHEMICAL DEVICE | SHENZHEN BTR NEW ENERGY TECHNOLOGY RESEARCH INSTITUTE CO., LTD. (CN) | 2025-01-16 | — | — | US | claimed |
| US-20240327571-A1 | CROSSLINKED POLYMER ELASTOMERS, COMPOSITIONS, AND METHODS OF PREPARATION THEREOF | MOMENTIVE PERFORMANCE MAT INC (US) | 2024-10-03 | — | — | US | claimed |
| WO-2021120953-A1 | METHOD FOR SYNTHESIZING 1,7-NAPHTHYRIDINE DERIVATIVE | 诚达药业股份有限公司 | 2021-06-24 | — | — | WO | claimed |
| CN-110885329-B | Synthetic method of 1, 7-naphthyridine derivative | 诚达药业股份有限公司 | 2020-12-15 | — | — | CN | claimed |
| US-20200388880-A1 | SILICON-BASED ENERGY STORAGE DEVICES WITH ELECTROLYTE ADDITIVE COMPOUNDS | ENEVATE CORPORATION | 2020-12-10 | — | — | US | claimed |
| CN-111393262-A | Water removal method for alcohol solvent | 六盘水师范学院 | 2020-07-10 | — | — | CN | claimed |
| CN-111138335-A | Preparation method of optically active 2-methylproline | 山东四环药业股份有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-110964011-A | Synthetic method of 8-chloro-1, 7-naphthyridine-3-formaldehyde | 诚达药业股份有限公司 | 2020-04-07 | — | — | CN | claimed |
| CN-110885329-A | Synthetic method of 1, 7-naphthyridine derivative | 诚达药业股份有限公司 | 2020-03-17 | — | — | CN | claimed |
| US-4983320-A | Tertiary amine decomposition catalysts; polyurethane foams | AKZO N.V. (NL) | 1991-01-08 | — | — | US | claimed |
| EP-0060808-B1 | 4-CHLORO-4-CHLOROMETHYLOXETAN-2-ONE AND PROCESS FOR ITS PREPARATION | CIBA-GEIGY AG (CH) | 1985-07-24 | — | — | EP | claimed |
| US-4398033-A | 4-Chloro-4-chloromethyloxetan-2-one and a process for its production | CIBA-GEIGY CORPORATION (US) | 1983-08-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200388880-A1 | SILICON-BASED ENERGY STORAGE DEVICES WITH ELECTROLYTE ADDITIVE COMPOUNDS | SOST, CA1, DUOX2 | FFAR3 3894/4885CA1 2/4885CA2 11/4885 |
| US-12234234-B2 | Method for synthesizing 1,7-naphthyridine derivatives | ALDH7A1, AKR7A2, APEH | FFAR3 3918/4885CA1 1106/4885CA2 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.