Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL591922 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL1127897 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28893179 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL28363045 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL288699 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL10955970 | 1.00 | FFAR3 (0.58) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL7151962 | 1.00 | — | — | |
| Bicarbonate SCHEMBL20586919 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL9435869 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 | |
| Bicarbonate SCHEMBL17023327 | 0.95 | FFAR3 (0.54) | FFAR3CA1CA2CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5287113-A | — | — | None | — | — | JP | disclosed |
| CN-115335045-B | Modulators of mutation bestrophin for the treatment of BEST 1-related retinopathy | 雷根斯堡大学 | 2025-03-18 | — | — | CN | disclosed |
| CN-115335045-A | Mutant bestrophin 1 modulators for the treatment of BEST 1-related retinopathy | 雷根斯堡大学 | 2022-11-11 | — | — | CN | disclosed |
| US-10758478-B2 | Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same | LABORATORY SKIN CARE, INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-8030501-B2 | Process for producing optically active 3-amino nitrogen-containing compounds | KANEKA CORPORATION (JP) | 2011-10-04 | — | — | US | disclosed |
| US-20090326246-A1 | Method for Production of Optically Active 3-Amino-Nitrogenated Compound | KANEKA CORPORATION (JP) | 2009-12-31 | — | — | US | disclosed |
| EP-2050735-A1 | METHOD FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-NITROGENATED COMPOUND | Kaneka Corporation (JP) | 2009-04-22 | — | — | EP | disclosed |
| US-7482415-B2 | Process for producing fluoroionomer, method for purification and concentration of the ionomer, and method of film formation | DAIKIN INDUSTRIES, LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| EP-1283225-B1 | PROCESS FOR PRODUCING FLUOROIONOMER, METHOD FOR PURIFICATION AND CONCENTRATION OF THE IONOMER, AND METHOD OF FILM FORMATION | DAIKIN IND LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1283225-A1 | PROCESS FOR PRODUCING FLUOROIONOMER, METHOD FOR PURIFICATION AND CONCENTRATION OF THE IONOMER, AND METHOD OF FILM FORMATION | Daikin Industries, Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-4871780-A | VINYL HALIDES AND ACRYLATED POLYCAPROLACTONE COPOLYMERIZED | THE B.F. GOODRICH COMPANY (US) | 1989-10-03 | — | — | US | disclosed |
| US-4871801-A | ANHYDRIDE-FUNCTIONALIZED COPOLYMER OF VINYL HALIDE AND ETHYLENICALLY UNSATURATED HYDROXY-CONTAINING MONOMER, REACTED WITH SECOND COREACTIVE MOIETY | THE B. F. GOODRICH COMPANY (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0177956-B1 | LOW MOLECULAR WEIGHT VINYL HALIDE/VINYL ESTER COPOLYMERS BY AQUEOUS POLYMERIZATION | The B.F. GOODRICH Company (US) | 1989-04-19 | — | — | EP | disclosed |
| US-4797458-A | MOLDING MATERIALS | THE B.F. GOODRICH COMPANY (US) | 1989-01-10 | — | — | US | disclosed |
| CN-87106075-A | Use the colloid-stabilised ethylene halide polyreaction of amine-thiol chain transfer agents | — | 1988-06-29 | — | — | CN | disclosed |
| EP-0258832-A2 | Colloidal stable vinyl halide polymerizations with mercaptan chain transfer agents | THE B.F. GOODRICH COMPANY (US) | 1988-03-09 | — | — | EP | disclosed |
| EP-0243820-A2 | Low molecular weight copolymers of vinyl halide/vinyl acetate produced by aqueous polymerization | The B.F. GOODRICH Company (US) | 1987-11-04 | — | — | EP | disclosed |
| CN-85107445-A | Make the multipolymer of lower molecular weight halogen ethylene/vinyl ester by the water polyreaction | — | 1986-09-03 | — | — | CN | disclosed |
| EP-0177956-A2 | Low molecular weight vinyl halide/vinyl ester copolymers by aqueous polymerization | The B.F. GOODRICH Company (US) | 1986-04-16 | — | — | EP | disclosed |
| EP-0030439-A2 | Polymerisation process for preparation of non-aqueous dispersions of microparticles and coating compositions containing said microparticles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10758478-B2 | Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same | CHERP, ORAI1, CA2 | FFAR3 3335/4885CA1 67/4885CA2 3/4885 |
| US-20090326246-A1 | Method for Production of Optically Active 3-Amino-Nitrogenated Compound | PNMT, NPEPPS, GNMT | FFAR3 534/4885CA1 3988/4885CA2 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.