Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 7/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11279949 | 0.97 | HIF1A (0.42) | HIF1ALMNAALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11279956 | 0.83 | HIF1A (0.54) | HIF1ALMNAALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11284482 | 0.82 | TBXA2R (0.37) | ALDH1A1ADRB2PMP22ADRB1TDP1 | |
| SCHEMBL11287818 | 0.82 | PMP22 (0.35) | HIF1ALMNAADRB2PMP22CYP1A2 | |
| Alcohol SCHEMBL11286257 | 0.81 | SLC2A1 (0.38) | LMNAALDH1A1CYP3A4ADRB2CYP1A2 | |
| Alcohol SCHEMBL11281555 | 0.80 | ALDH1A1 (0.36) | HIF1ALMNAALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11279951 | 0.79 | HIF1A (0.42) | HIF1ALMNAALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11286259 | 0.77 | SLC2A1 (0.40) | LMNAALDH1A1CYP3A4ADRB2CYP1A2 | |
| SCHEMBL11288592 | 0.77 | HIF1A (0.40) | HIF1ALMNAALDH1A1CYP3A4ADRB2 | |
| SCHEMBL11277350 | 0.77 | TBXA2R (0.36) | ADRB2PMP22CYP2D6ADRB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336400-A | BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS | STERLING DRUG INC. (US) | 1982-06-22 | — | — | US | claimed |