Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.42 |
| ▸ | TNKS | O95271 | 4/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274910 | 0.81 | PARP1 (0.49) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL11285870 | 0.80 | PARP1 (0.45) | PARP1TNKS2TNKSPARP15ALDH1A1 | |
| SCHEMBL11274767 | 0.79 | MAPK1 (0.48) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL11288925 | 0.75 | MAPK1 (0.44) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL1561103 | 0.73 | PARP1 (0.45) | PARP1TNKS2TNKSPARP15ALDH1A1 | |
| SCHEMBL11647198 | 0.72 | TLR8 (0.47) | PARP1TNKS2TNKSPARP15ALDH1A1 | |
| SCHEMBL1560390 | 0.70 | PARP1 (0.41) | PARP1TNKS2TNKSPARP15ALDH1A1 | |
| SCHEMBL7980353 | 0.69 | PARP1 (0.54) | PARP1TNKS2TNKSPARP15PIM1 | |
| SCHEMBL11281218 | 0.69 | TLR8 (0.51) | PARP1TNKS2TNKSPARP15ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4320664 | 0.69 | PARP1 (0.56) | PARP1TNKS2TNKSPARP15PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005745-B1 | PYRAZOLO (3,4-C) AND THIAZOLO (5,4-C) ISOQUINOLINES, METHODS FOR PREPARING THEM, THESE COMPOUNDS FOR USE AS ANTIINFLAMMATORY, CNS-DEPRESSANT AND ANTI-ANXIETY AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | GRUPPO LEPETIT S.P.A. (IT) | 1982-07-14 | — | — | EP | disclosed |
| EP-0005745-A1 | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, CNS-depressant and anti-anxiety agents and pharmaceutical compositions thereof | GRUPPO LEPETIT S.P.A. (IT) | 1979-12-12 | — | — | EP | disclosed |