Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257031 | 0.85 | SCN4A (0.37) | SCN4ASIGMAR1S1PR4ALDH1A1MAPT | |
| SCHEMBL11280937 | 0.83 | SCN4A (0.38) | SCN4ASIGMAR1S1PR4ALDH1A1MAPT | |
| SCHEMBL11280191 | 0.81 | SCN4A (0.35) | SCN4ASIGMAR1S1PR4ALDH1A1MAPT | |
| SCHEMBL11255220 | 0.78 | POLB (0.42) | SCN4AS1PR4ALDH1A1MAPT | |
| SCHEMBL11266545 | 0.76 | SCN4A (0.34) | SCN4ASIGMAR1S1PR4ALDH1A1MAPT | |
| SCHEMBL11260870 | 0.75 | POLB (0.35) | SCN4AS1PR4 | |
| SCHEMBL11286853 | 0.73 | SCN4A (0.38) | SCN4AS1PR4ALDH1A1MAPTLMNA | |
| SCHEMBL14868476 | 0.73 | ALDH1A1 (0.34) | SIGMAR1ALDH1A1MAPTLMNA | |
| SCHEMBL11255033 | 0.73 | TSHR (0.42) | SCN4AS1PR4ALDH1A1MAPTLMNA | |
| SCHEMBL11558131 | 0.71 | SCN4A (0.39) | SCN4AS1PR4ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |