Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280221 | 0.83 | SCN4A (0.34) | SCN4AS1PR4SIGMAR1ALDH1A1LMNA | |
| SCHEMBL10940676 | 0.82 | SCN4A (0.39) | SCN4AS1PR4MEN1PLA2G1BHTT | |
| SCHEMBL11558131 | 0.82 | SCN4A (0.39) | SCN4AS1PR4HSD17B1HSD17B2MEN1 | |
| SCHEMBL11560903 | 0.78 | POLB (0.45) | SCN4AS1PR4HSD17B1HSD17B2MEN1 | |
| SCHEMBL11562043 | 0.77 | MAPT (0.37) | SCN4AS1PR4MEN1PLA2G1BHTT | |
| SCHEMBL11557101 | 0.77 | LMNA (0.37) | SCN4AS1PR4POLBSIGMAR1ALDH1A1 | |
| SCHEMBL11563134 | 0.77 | POLB (0.47) | SCN4AMEN1HTTKMT2ANPSR1 | |
| SCHEMBL9020790 | 0.77 | SCN4A (0.37) | SCN4AS1PR4HSD17B1HSD17B2MEN1 | |
| SCHEMBL11257031 | 0.75 | SCN4A (0.37) | SCN4AS1PR4MEN1PLA2G1BHTT | |
| SCHEMBL11286853 | 0.74 | SCN4A (0.38) | SCN4AS1PR4HSD17B1HSD17B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |