Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | F7 | P08709 | 2/20 | 0.46 |
| ▸ | F3 | P13726 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934960 | 0.88 | FFAR1 (0.47) | SMN1; SMN2NPC1HPGDRAB9AFOLH1 | |
| SCHEMBL28815272 | 0.78 | CCR5 (0.49) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL9360975 | 0.77 | F2 (0.49) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL9360982 | 0.77 | F2 (0.49) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL11369147 | 0.77 | NPC1 (0.49) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL11107066 | 0.77 | NPC1 (0.53) | SMN1; SMN2NPC1HPGDRAB9AFOLH1 | |
| SCHEMBL5893913 | 0.77 | NPC1 (0.56) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL28953806 | 0.77 | NPC1 (0.53) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL9360282 | 0.76 | KDM4E (0.46) | SMN1; SMN2NPC1HPGDRAB9AF2 | |
| SCHEMBL10477773 | 0.76 | L3MBTL1 (0.43) | SMN1; SMN2NPC1RAB9AF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4363814-A | VASODILATORS AND CNS STIMULANTS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-12-14 | — | — | US | disclosed |
| US-4271158-A | Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones | BOEHRINGER INGELHEIM GMBH (US) | 1981-06-02 | — | — | US | disclosed |
| US-4215119-A | VASODILATORS, ANTIDEPRESSANTS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-07-29 | — | — | US | disclosed |
| US-4154829-A | ANTIDEPRESSANT, VASODILATION | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |