Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280303 | 0.79 | SIGMAR1 (0.72) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL11284564 | 0.77 | SIGMAR1 (0.64) | SIGMAR1OPRM1KCNH2TSHR | |
| SCHEMBL11228029 | 0.76 | OPRM1 (0.37) | SIGMAR1OPRM1KCNH2 | |
| SCHEMBL11282865 | 0.75 | OPRM1 (0.51) | SIGMAR1OPRM1KCNH2HTR2ADRD3 | |
| SCHEMBL11289188 | 0.74 | FASN (0.44) | SIGMAR1OPRM1KCNH2TSHRHTR1A | |
| SCHEMBL11224661 | 0.73 | OPRM1 (0.41) | SIGMAR1OPRM1KCNH2DRD2 | |
| SCHEMBL11281332 | 0.72 | TSHR (0.35) | TSHRHTR1ADRD2DRD4HTR2A | |
| SCHEMBL11279270 | 0.70 | SIGMAR1 (0.63) | SIGMAR1OPRM1KCNH2TSHR | |
| SCHEMBL11285434 | 0.70 | SIGMAR1 (0.52) | SIGMAR1OPRM1KCNH2TSHRHTR1A | |
| SCHEMBL11292614 | 0.70 | OPRM1 (0.39) | SIGMAR1OPRM1KCNH2TSHRHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |