Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | CASP5 | P51878 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11399972 | 0.97 | LMNA (0.57) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11282875 | 0.86 | LMNA (0.58) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11397097 | 0.84 | LMNA (0.59) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL9558892 | 0.84 | LMNA (0.56) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11278102 | 0.84 | LMNA (0.56) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11387689 | 0.83 | LMNA (0.55) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11307833 | 0.82 | LMNA (0.57) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4081369 | 0.82 | CASP1 (0.45) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11392029 | 0.81 | LMNA (0.56) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11397576 | 0.81 | LMNA (0.56) | LMNAHTTALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0022481-A1 | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions | Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) | 1981-01-21 | — | — | EP | disclosed |