Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11284052 | 0.99 | HTR2A (0.52) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL11289963 | 0.88 | HTR2A (0.51) | HTR2ADRD2DRD3HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL11281215 | 0.87 | HTR2A (0.50) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL11288183 | 0.86 | HTR2A (0.48) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL11291447 | 0.84 | SIGMAR1 (0.66) | HTR2AOPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11284430 | 0.83 | SIGMAR1 (0.64) | HTR2AOPRM1SIGMAR1 | |
| SCHEMBL11361104 | 0.83 | LMNA (0.63) | HTR2ADRD2DRD3HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL11361513 | 0.82 | MAPT (0.64) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL11286419 | 0.82 | HTR2A (0.53) | HTR2ADRD2DRD3HTR1ADRD4 | |
| SCHEMBL17319098 | 0.81 | SIGMAR1 (0.65) | ADRA2AOPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061333-A1 | 9-(2-(3-Indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones | SYNTEX (U.S.A.) INC. (US) | 1982-09-29 | — | — | EP | claimed |
| US-4332804-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, ARRHYTHMIA, MIGRAINE, VASOSPASTIC DISORDERS AND ASTHMA | SYNTEX (U.S.A.) INC. (US) | 1982-06-01 | — | — | US | claimed |