SCHEMBL11282803

SCHEMBL11282803

CSC(C)=C(CC(=O)O)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LDHA P00338 1/20 0.32
SRR Q9GZT4 1/20 0.32
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11282801 1.00 LDHA (0.32) LDHASRRALDH1A1MAPT
SCHEMBL3622920 0.70 LDHA (0.40) LDHASRRALDH1A1
SCHEMBL16082013 0.67 FFAR3 (0.31)
Trifluoroacetic Acid SCHEMBL28035892 0.63 LDHA (0.60) LDHASRRALDH1A1
SCHEMBL5886478 0.63
SCHEMBL2976771 0.62 FFAR3 (0.35) ALDH1A1
SCHEMBL14776283 0.62 FFAR3 (0.35) ALDH1A1
SCHEMBL1059262 0.61 LDHA (0.47) LDHASRRALDH1A1
SCHEMBL28767792 0.61 LDHA (0.47) LDHASRRALDH1A1
Acetoacetic Acid SCHEMBL27708905 0.61 KDM4E (0.48) LDHASRRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325877-A Production of intermediates for enzyme inhibitors RICHARDSON-MERRELL INC. (US) 1982-04-20 US disclosed