Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29175032 | 1.00 | ALDH1A1 (0.56) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL11281655 | 1.00 | ALDH1A1 (0.56) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL29107678 | 0.86 | ALDH1A1 (0.53) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL11394318 | 0.83 | MEN1 (0.52) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL11391576 | 0.83 | MEN1 (0.52) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL7361524 | 0.83 | MEN1 (0.69) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL7427522 | 0.83 | MEN1 (0.69) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL5002689 | 0.83 | ALDH1A1 (0.58) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL756835 | 0.81 | ALDH1A1 (0.54) | ALDH1A1POLBCYP2C19MEN1KMT2A | |
| SCHEMBL756836 | 0.81 | ALDH1A1 (0.54) | ALDH1A1POLBCYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000718-B1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS AND THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-03-24 | — | — | EP | disclosed |