Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3898377 | 0.84 | ALOX15 (0.74) | ALOX15GAAKMT2AMEN1ALPL | |
| SCHEMBL5071825 | 0.81 | ALOX15 (0.50) | ALOX15CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL571951 | 0.80 | PKM (0.50) | ALOX15CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL1345641 | 0.80 | ALOX15 (0.57) | ALOX15CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL11956755 | 0.79 | ALOX15 (0.65) | ALOX15GAAKMT2AMEN1ALPL | |
| SCHEMBL27789509 | 0.77 | CYP2C9 (0.59) | ALOX15CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL15396047 | 0.77 | ALOX15 (0.68) | ALOX15GAAKMT2AMEN1ALPL | |
| SCHEMBL24487000 | 0.76 | TSHR (0.48) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL16383050 | 0.76 | ALOX15 (0.57) | ALOX15CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28858275 | 0.76 | ALOX15 (0.57) | ALOX15CYP2C9CYP2C19GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947633-A | Synthesis method of tafluprost | 广州楷石医药有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116425707-A | Tafluprost intermediate isomer impurity and preparation method thereof | 南京华威医药科技集团有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-0025687-B1 | 15-METHANESULFONAMIDOPROSTAGLANDIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF AND PROCESS THEREFOR | PFIZER INC. (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0025687-A1 | 15-Methanesulfonamidoprostaglandin derivatives, pharmaceutical compositions thereof and process therefor | PFIZER INC. (US) | 1981-03-25 | — | — | EP | disclosed |