Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288334 | 0.90 | DRD2 (0.53) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11280131 | 0.90 | DRD2 (0.57) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11287182 | 0.90 | DRD2 (0.57) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11277513 | 0.90 | DRD2 (0.56) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11285556 | 0.88 | DRD2 (0.44) | DRD2DRD3ADRA1ALMNADRD4 | |
| SCHEMBL11283016 | 0.88 | DRD2 (0.53) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11282980 | 0.86 | DRD2 (0.41) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11292863 | 0.83 | DRD2 (0.51) | DRD2HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL11284826 | 0.81 | LMNA (0.54) | DRD2ADRA2ACYP2D6OPRM1KCNH2 | |
| SCHEMBL11277984 | 0.79 | DRD2 (0.47) | DRD2HTR2ADRD3HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |