⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298368 | 0.78 | PDE10A (0.39) | — | |
| SCHEMBL8461698 | 0.73 | CCR1 (0.32) | — | |
| SCHEMBL3315761 | 0.73 | ALDH1A1 (0.50) | — | |
| SCHEMBL24512545 | 0.72 | LMNA (0.33) | — | |
| SCHEMBL5674970 | 0.69 | S1PR2 (0.34) | — | |
| SCHEMBL17395923 | 0.67 | MEN1 (0.30) | — | |
| SCHEMBL218726 | 0.63 | ALDH1A1 (0.54) | — | |
| SCHEMBL18301222 | 0.62 | CYP1A2 (0.40) | — | |
| SCHEMBL9418468 | 0.61 | POLB (0.35) | — | |
| SCHEMBL7992334 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188098-B2 | GPR119 receptor agonists | HOFFMANN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| CN-102036991-A | GPR119 receptor agonists | HOFFMANN LA ROCHE | 2011-04-27 | — | — | CN | disclosed |
| EP-2283019-A1 | GPR119 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | disclosed |
| US-20090286812-A1 | GPR119 Receptor Agonists | ERICKSON SHAWN DAVID | 2009-11-19 | — | — | US | disclosed |