Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | SHBG | P04278 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proxazole SCHEMBL8935625 | 0.78 | CYP1A2 (0.68) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Proxazole SCHEMBL41604 | 0.78 | CYP1A2 (0.68) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL348107 | 0.72 | LMNA (0.83) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL547295 | 0.72 | LMNA (0.83) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL2313103 | 0.71 | ESR1 (0.75) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL28378622 | 0.71 | LMNA (0.81) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL17419498 | 0.70 | ESR1 (0.83) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL1903738 | 0.70 | LMNA (0.83) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Estradiol SCHEMBL6862949 | 0.70 | ESR1 (0.83) | ESR1LMNAKMT2AMAPTSMN1; SMN2 | |
| Citric Acid SCHEMBL11209406 | 0.70 | ESR1 (0.62) | ESR1LMNAKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064900-A1 | Electromagnetic system with correlation detection and proximity fuze using said system | THOMSON-CSF (FR) | 1982-11-17 | — | — | EP | disclosed |