Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Proxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.51 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 9/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proxazole SCHEMBL41604 | 1.00 | CYP1A2 (0.68) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL21827680 | 0.92 | CYP1A2 (0.59) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL28279739 | 0.86 | HTR1A (0.59) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL24319 | 0.86 | HTR1A (0.59) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Oxolamine SCHEMBL3498928 | 0.81 | CYP1A2 (1.00) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL28142080 | 0.79 | HTR1A (0.52) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL937982 | 0.79 | TDP1 (0.51) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Proxazole SCHEMBL11286830 | 0.78 | ESR1 (0.47) | CYP1A2CYP2D6HIF1ALMNAMEN1 | |
| Oxolamine SCHEMBL4414451 | 0.70 | CYP1A2 (0.78) | CYP1A2CYP2D6HIF1AKDM4ELMNA | |
| Butetamate SCHEMBL317018 | 0.69 | KDM4E (1.00) | CYP1A2CYP2D6HIF1AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577766-A4 | APPARATUS AND METHOD FOR HIGH THROUGHPUT SPUTTERING | CONNER PERIPHERALS INC (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0577766-A1 | APPARATUS AND METHOD FOR HIGH THROUGHPUT SPUTTERING | CONNER PERIPHERALS, INC. (US) | 1994-01-12 | — | — | EP | disclosed |