Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288206 | 0.86 | SIGMAR1 (0.45) | SIGMAR1OPRM1MEN1LMNAMAPT | |
| SCHEMBL11289188 | 0.86 | FASN (0.44) | SIGMAR1OPRM1MEN1LMNAMAPT | |
| SCHEMBL11281374 | 0.82 | SIGMAR1 (0.41) | SIGMAR1OPRM1MEN1LMNAMAPT | |
| SCHEMBL17543847 | 0.79 | KMT2A (0.44) | MEN1LMNAMAPTKMT2AHTR1A | |
| SCHEMBL11285195 | 0.77 | LMNA (0.41) | MEN1LMNAMAPTKMT2AHTR1A | |
| SCHEMBL11284564 | 0.77 | SIGMAR1 (0.64) | SIGMAR1OPRM1KCNH2TSHR | |
| SCHEMBL23015975 | 0.75 | SIGMAR1 (0.79) | SIGMAR1OPRM1DRD2KCNH2 | |
| SCHEMBL11289006 | 0.75 | LMNA (0.39) | MEN1LMNAMAPTKMT2AHTR1A | |
| SCHEMBL11279270 | 0.75 | SIGMAR1 (0.63) | SIGMAR1OPRM1KCNH2TSHR | |
| SCHEMBL11287195 | 0.74 | SIGMAR1 (1.00) | SIGMAR1OPRM1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |