SCHEMBL11287246

SCHEMBL11287246

O=C(C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.61
HDAC7 Q8WUI4 1/20 0.61
HDAC5 Q9UQL6 1/20 0.61
BRD4 O60885 1/20 0.50
S1PR1 P21453 1/20 0.49
S1PR3 Q99500 1/20 0.49
CES2 O00748 1/20 0.46
CES1 P23141 1/20 0.46
CNR1 P21554 2/20 0.44
TSHR P16473 5/20 0.44
ALOX15 P16050 2/20 0.44
MAPK1 P28482 2/20 0.44
HIF1A Q16665 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
GABBR2 O75899 3/20 0.44
GABBR1 Q9UBS5 3/20 0.44
LMNA P02545 3/20 0.44
CYP2C9 P11712 2/20 0.44
FFAR2 O15552 1/20 0.44
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16781990 0.91 CNR1 (0.56) HDAC4HDAC7HDAC5S1PR1S1PR3
SCHEMBL467546 0.82 HDAC4 (0.59) HDAC4HDAC7HDAC5BRD4S1PR1
SCHEMBL933979 0.82 HDAC4 (0.59) HDAC4HDAC7HDAC5BRD4S1PR1
SCHEMBL3739983 0.80 HDAC4 (0.57) HDAC4HDAC7HDAC5BRD4S1PR1
SCHEMBL10882007 0.80 BRD4 (0.63) HDAC4HDAC7HDAC5BRD4S1PR1
Hydrochloric Acid SCHEMBL933980 0.80 HDAC4 (0.57) HDAC4HDAC7HDAC5BRD4S1PR1
SCHEMBL9337191 0.77 CNR1 (0.56) HDAC4HDAC7HDAC5S1PR1S1PR3
SCHEMBL2848402 0.77 HDAC4 (1.00) HDAC4HDAC7HDAC5BRD4S1PR1
SCHEMBL5843647 0.76 ESR1 (0.48) CNR1TSHRALOX15HIF1ATDP1
SCHEMBL2542929 0.75 HDAC4 (0.47) HDAC4HDAC7HDAC5BRD4S1PR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4344954-A DIURETICS AMERICAN CYANAMID COMPANY (US) 1982-08-17 US disclosed
US-4169951-A PROCESS FOR THE PRODUCTION OF SUBSTITUTED PYRIDINE (B) DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1979-10-02 US disclosed