Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10645106 | 0.83 | FAAH (0.56) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL425400 | 0.77 | FAAH (0.54) | MAP4K4ALDH1A1KMOFAAHSMN1; SMN2 | |
| SCHEMBL424650 | 0.75 | MAP4K4 (0.39) | MAP4K4KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL427057 | 0.75 | FAAH (0.63) | MAP4K4NPC1RAB9AFAAHPOLB | |
| SCHEMBL426706 | 0.75 | GPBAR1 (0.46) | MAP4K4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14946886 | 0.75 | FAAH (0.43) | MAP4K4KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL425811 | 0.74 | FAAH (0.65) | MAP4K4HPGDNPC1RAB9AFAAH | |
| SCHEMBL11286521 | 0.74 | KIF11 (0.43) | KDM4EALPLKDM4C | |
| SCHEMBL427826 | 0.72 | FAAH (0.49) | KDM4EFAAHLMNAMAPT | |
| SCHEMBL427118 | 0.72 | DPP4 (0.40) | MAP4K4KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011769-B1 | HYDROXYETHYL AZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1982-04-14 | — | — | EP | disclosed |
| EP-0005250-B1 | HYDROXYPROPYL IMIDAZOLES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | BAYER AG (DE) | 1981-08-12 | — | — | EP | disclosed |
| EP-0011769-A1 | Hydroxyethyl azoles, process for their preparation and their use in medicaments | BAYER AG (DE) | 1980-06-11 | — | — | EP | disclosed |
| EP-0005250-A2 | Hydroxypropyl imidazoles, their preparation and medicaments containing them | BAYER AG (DE) | 1979-11-14 | — | — | EP | disclosed |