Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.32 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.32 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915123 | 0.76 | OPRM1 (0.39) | OPRM1OPRD1OPRK1HTR2ASLC6A4 | |
| SCHEMBL8588165 | 0.75 | HTR2A (0.39) | OPRM1OPRD1OPRK1HTR2ASLC6A4 | |
| SCHEMBL3958256 | 0.72 | MAPT (0.37) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL15210113 | 0.69 | HTR2A (0.34) | OPRM1OPRD1OPRK1HTR2ASLC6A4 | |
| SCHEMBL5863813 | 0.69 | OPRM1 (0.42) | OPRM1OPRD1OPRK1HTR2ASLC6A4 | |
| SCHEMBL28137826 | 0.67 | TSHR (0.31) | — | |
| SCHEMBL16150146 | 0.67 | SIGMAR1 (0.42) | OPRM1OPRD1OPRK1OPRL1SIGMAR1 | |
| Methylamine SCHEMBL27471205 | 0.67 | OPRM1 (0.40) | OPRM1OPRD1OPRK1HTR2ASLC6A4 | |
| SCHEMBL5915111 | 0.67 | OPRM1 (0.40) | OPRM1HTR2ASIGMAR1 | |
| SCHEMBL28287844 | 0.67 | OPRM1 (0.37) | OPRM1OPRL1HTR2ACYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067769-A1 | 1,2,3,4,4a,9b-Hexahydro-4a-piperazinylmethyl-4-dibenzofuranones or substituted 4-dibenzofuranoles, process for their preparation and their therapeutic use | RIOM LABORATOIRES- C.E.R.M. (Société Anonyme) (FR) | 1982-12-22 | — | — | EP | disclosed |