Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | BLM | P54132 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 11/20 | 0.98 |
| ▸ | MAPT | P10636 | 5/20 | 0.98 |
| ▸ | MTOR | P42345 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | THPO | P40225 | 3/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | DRD2 | P14416 | 6/20 | 0.83 |
| ▸ | DRD5 | P21918 | 1/20 | 0.72 |
| ▸ | GMNN | O75496 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390591 | 0.99 | DRD1 (1.00) | KDM4EBLMPMP22LMNADRD1 | |
| Hydrochloric Acid SCHEMBL7203243 | 0.98 | DRD1 (1.00) | KDM4EBLMPMP22LMNADRD1 | |
| SCHEMBL10745918 | 0.85 | DRD1 (0.75) | KDM4EBLMPMP22LMNADRD1 | |
| Hydrochloric Acid SCHEMBL10747243 | 0.84 | DRD1 (0.76) | KDM4EBLMPMP22LMNADRD1 | |
| SCHEMBL11605631 | 0.84 | DRD2 (0.76) | KDM4EBLMPMP22LMNADRD1 | |
| Bromide SCHEMBL11539891 | 0.84 | KDM4E (0.72) | KDM4EBLMPMP22LMNADRD1 | |
| Hydrochloric Acid SCHEMBL10345839 | 0.83 | DRD1 (0.74) | KDM4EBLMPMP22LMNADRD1 | |
| SCHEMBL14510732 | 0.82 | DRD1 (0.82) | KDM4EBLMPMP22LMNADRD1 | |
| Bromide SCHEMBL11721722 | 0.82 | KDM4E (0.71) | KDM4EBLMPMP22LMNADRD1 | |
| SCHEMBL11157379 | 0.81 | DRD1 (0.70) | KDM4EBLMPMP22LMNADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | claimed |
| EP-2806276-A1 | Method for post mortem diagnosis of Alzheimer's Disease (AD) | Red Bull GmbH (AT) | 2014-11-26 | — | — | EP | claimed |
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | disclosed |
| EP-2806276-A1 | Method for post mortem diagnosis of Alzheimer's Disease (AD) | Red Bull GmbH (AT) | 2014-11-26 | — | — | EP | disclosed |
| US-4342686-A | Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| US-4265889-A | DOPAMINERGIC, HYPOTENSIVE | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |