SCHEMBL11288752

SCHEMBL11288752

C[Si](C)(C)OC(Cc1ccccc1)(Cc1ccccc1)C(=O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 2/20 0.41
SRC P12931 1/20 0.41
HIF1A Q16665 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SLC6A2 P23975 2/20 0.40
SLC6A3 Q01959 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PTPN1 P18031 1/20 0.38
ALDH1A1 P00352 3/20 0.37
RECQL P46063 1/20 0.37
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
MMP8 P22894 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29924395 0.78 PPARG (0.45) HIF1ASMN1; SMN2KMT2ATDP1ALDH1A1
SCHEMBL10385943 0.75 CES1 (0.46) CES1SRCHIF1ATDP1ALDH1A1
SCHEMBL7910874 0.75 CES1 (0.37) CES1SRCSMN1; SMN2KMT2ATDP1
SCHEMBL7104524 0.73 SLC6A2 (0.52) CES1SRCHIF1ASMN1; SMN2SLC6A2
SCHEMBL8459206 0.73 MMP8 (0.50) CES1SRCHIF1ASMN1; SMN2SLC6A2
SCHEMBL28536864 0.72 CES1 (0.51) CES1SRCHIF1ASMN1; SMN2SLC6A2
SCHEMBL8994348 0.72 SRC (0.46) CES1SRCHIF1ASMN1; SMN2SLC6A2
SCHEMBL6916221 0.71 CES1 (0.50) CES1SRCHIF1AKMT2ATDP1
SCHEMBL14518075 0.71 SMN1; SMN2 (0.48) CES1SRCHIF1ASMN1; SMN2SLC6A2
SCHEMBL4984505 0.70 SMN1; SMN2 (0.44) CES1SRCHIF1ASMN1; SMN2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4351708-A A COCATALYST MIXTURE OF AN AROMATIC IODONIUM SALT, AN AROMATIC CARBONYL PHOTOINITIATOR AND A FREE RADICAL CATALYST CIBA-GEIGY CORPORATION (US) 1982-09-28 US disclosed
EP-0007468-B1 COMPOSITIONS PHOTODURCISSABLES CIBA-GEIGY AG (CH) 1982-04-07 EP disclosed
US-4284485-A STABILIZED WITH A POLYALKYLPIPERIDINE DERIVATIVE CIBA-GEIGY CORPORATION (US) 1981-08-18 US disclosed