Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylaminoethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylaminoethanol SCHEMBL20677258 | 0.92 | MAPT (0.75) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Dimethylaminoethanol SCHEMBL28282228 | 0.86 | MAPT (0.75) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Dimethylaminoethanol SCHEMBL2586281 | 0.86 | — | — | |
| Dimethylaminoethanol SCHEMBL10935556 | 0.85 | MAPT (0.57) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Diethylaminoethanol SCHEMBL4773320 | 0.83 | MAPT (0.55) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Monoethanolamine SCHEMBL29132870 | 0.83 | MAPT (0.59) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Dimethylaminoethanol SCHEMBL29771321 | 0.83 | MAPT (0.80) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Monoethanolamine SCHEMBL3377894 | 0.81 | MAPT (0.50) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Monoethanolamine SCHEMBL6103998 | 0.80 | MAPT (0.56) | MAPTALDH1A1TSHRTDP1CYP2C9 | |
| Alcohol SCHEMBL6679572 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049098-A1 | Cross-linked polymer compositions and production thereof | The British Petroleum Company p.l.c. (GB) | 1982-04-07 | — | — | EP | disclosed |