Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11572303 | 0.92 | KDM4E (0.37) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11290085 | 0.90 | PAOX (0.38) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5698060 | 0.89 | CA12 (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31306912 | 0.89 | CA12 (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11569953 | 0.84 | ALDH1A1 (0.37) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8380519 | 0.81 | CA1 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9717113 | 0.80 | F2 (0.45) | CA12CA1CA2CA7CA9 | |
| SCHEMBL29049264 | 0.76 | CA12 (0.48) | CA12CA1CA2CA7CA9 | |
| Ethylenediamine SCHEMBL11297757 | 0.74 | F2 (0.35) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| Ethylenediamine SCHEMBL11627367 | 0.72 | F2 (0.42) | PTPN1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4328357-A | Process for preparing nitrogen compounds | SAYTECH, INC. (US) | 1982-05-04 | — | — | US | disclosed |
| US-4140862-A | Salts of diamines and tetrahalophthalates | CITIES SERVICE COMPANY (US) | 1979-02-20 | — | — | US | disclosed |