Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783160 | 0.94 | F2 (0.34) | F2PRSS1PRSS2PRSS3SERPINE1 | |
| SCHEMBL27457725 | 0.86 | TDP1 (0.38) | F2PRSS1PRSS2PRSS3SERPINE1 | |
| Ethylenediamine SCHEMBL11627367 | 0.85 | F2 (0.42) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL4456791 | 0.85 | ALDH1A1 (0.33) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29445809 | 0.84 | — | — | |
| SCHEMBL11871467 | 0.80 | ESR1 (0.50) | NPC1RAB9AALDH1A1TP53CYP3A4 | |
| SCHEMBL10717061 | 0.80 | THRB (0.45) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL9157297 | 0.78 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1CYP3A4HPGD | |
| SCHEMBL8470318 | 0.78 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1TP53CYP3A4 | |
| SCHEMBL7946728 | 0.78 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4328357-A | Process for preparing nitrogen compounds | SAYTECH, INC. (US) | 1982-05-04 | — | — | US | disclosed |
| US-4140862-A | Salts of diamines and tetrahalophthalates | CITIES SERVICE COMPANY (US) | 1979-02-20 | — | — | US | disclosed |