SCHEMBL11289753

SCHEMBL11289753

COc1ccc(N)c(N=C=O)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.47
ALDH1A1 P00352 6/20 0.47
TDP1 Q9NUW8 4/20 0.46
HPGD P15428 2/20 0.46
MEN1 O00255 3/20 0.43
MAPT P10636 3/20 0.43
KMT2A Q03164 3/20 0.43
THRB P10828 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
MCL1 Q07820 1/20 0.42
NOS2 P35228 2/20 0.41
MAPK1 P28482 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10316751 0.83 ALDH1A1 (0.55) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL2487882 0.81 CYP3A4 (0.49) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL374346 0.80 ALDH1A1 (0.56) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL29538723 0.80 ALDH1A1 (0.56) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL12677097 0.79 ALDH1A1 (0.52) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL4047507 0.79 CYP3A4 (0.46) CYP3A4ALDH1A1TDP1HPGDMAPT
SCHEMBL7774163 0.79 ALDH1A1 (0.46) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL28014624 0.77 ALDH1A1 (0.41) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL29541267 0.76 ALDH1A1 (0.71) CYP3A4ALDH1A1TDP1HPGDMEN1
SCHEMBL703276 0.76 ALDH1A1 (0.71) CYP3A4ALDH1A1TDP1HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0063387-A1 Electrophotographic plate MITSUBISHI KASEI CORPORATION (JP) 1982-10-27 EP disclosed