Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129051 | 0.86 | KMT2A (0.40) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL3269719 | 0.86 | ALDH1A1 (0.58) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL436153 | 0.81 | ALDH1A1 (0.63) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL827359 | 0.74 | KMT2A (0.58) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL4349193 | 0.74 | KMT2A (0.41) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL266609 | 0.74 | ALDH1A1 (0.66) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL29727934 | 0.74 | ALDH1A1 (0.66) | KDM4EKMT2APOLBHSD17B10GAA | |
| SCHEMBL18462380 | 0.73 | ALDH1A1 (0.52) | KMT2APOLBALDH1A1HPGDUSP2 | |
| SCHEMBL14601538 | 0.73 | KMT2A (0.43) | KDM4EKMT2APOLBALDH1A1HPGD | |
| SCHEMBL8741313 | 0.73 | KMT2A (0.56) | KDM4EKMT2APOLBHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |