Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 4/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129510 | 0.87 | CYP17A1 (0.36) | CYP11B2CYP2C19CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL1129250 | 0.74 | KDM4E (0.37) | CYP11B2CYP19A1ALDH1A1 | |
| SCHEMBL8246810 | 0.69 | CYP11B2 (0.36) | CYP11B2CYP19A1CYP2C19ALDH1A1CYP17A1 | |
| SCHEMBL3617961 | 0.68 | CYP11B2 (0.37) | CYP11B2CYP19A1CYP2C19CYP17A1CYP1A2 | |
| SCHEMBL1129473 | 0.68 | CYP19A1 (0.38) | CYP11B2CYP19A1BACE1KCNH2CYP11B1 | |
| SCHEMBL1129508 | 0.68 | KDM4E (0.35) | CYP11B2CYP19A1ALDH1A1BACE1KCNH2 | |
| SCHEMBL1129482 | 0.67 | CYP19A1 (0.35) | CYP11B2CYP19A1ALDH1A1BACE1KCNH2 | |
| SCHEMBL1129448 | 0.66 | CYP11B2 (0.35) | CYP11B2CYP19A1CYP11B1 | |
| SCHEMBL1128983 | 0.66 | CYP19A1 (0.37) | CYP11B2CYP19A1ALDH1A1CYP17A1CYP11B1 | |
| SCHEMBL1129884 | 0.66 | CYP19A1 (0.37) | CYP11B2CYP19A1BACE1KCNH2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071774-B2 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2011-12-06 | — | — | US | disclosed |
| EP-1896481-B1 | HETEROCYCLIC SPIRO-COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| US-20100010015-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | NOVARTIS AG (CH) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010015-A1 | Heterocyclic spiro-compounds as aldosterone synthase inhibitors | REN, NR3C2, CYP21A2 | CYP11B2 15/4885CYP19A1 67/4885CYP2C19 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.