Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288483 | 0.89 | MAPT (0.55) | MAPTMAPK1NPC1HTTKMT2A | |
| SCHEMBL31406957 | 0.87 | MAPT (0.50) | MAPTMAPK1NPC1HTTRAB9A | |
| SCHEMBL11131815 | 0.85 | MAPT (0.51) | MAPTTDP1MAPK1NPC1HTT | |
| SCHEMBL11319565 | 0.84 | MAPT (0.48) | MAPTTDP1MAPK1NPC1HTT | |
| SCHEMBL11295078 | 0.84 | MAPT (0.51) | MAPTMAPK1NPC1HTTMEN1 | |
| SCHEMBL11286617 | 0.84 | MAPT (0.53) | MAPTMAPK1NPC1HTTMEN1 | |
| SCHEMBL11296771 | 0.82 | MAPT (0.46) | MAPTMAPK1NPC1HTTMEN1 | |
| SCHEMBL11288356 | 0.81 | MAPT (0.48) | MAPTTDP1MAPK1NPC1HTT | |
| SCHEMBL8320768 | 0.81 | MAPT (0.54) | MAPTTDP1MAPK1NPC1HTT | |
| SCHEMBL19010187 | 0.81 | MAPT (0.71) | MAPTTDP1MAPK1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065874-A1 | 2-Aminophenol derivatives, methods for their preparation and composition containing the same | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-12-01 | — | — | EP | disclosed |