Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032456 | 0.97 | CES2 (0.51) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL52137 | 0.90 | MAPT (0.60) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL19010187 | 0.87 | MAPT (0.71) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL10877792 | 0.84 | FLT1 (0.55) | MAPTNPC1MAPK1HTTCES2 | |
| SCHEMBL10954535 | 0.83 | MAPT (0.54) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL7271917 | 0.83 | SRD5A2 (0.60) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL145078 | 0.83 | MAPT (0.61) | MAPTNPC1MAPK1HTTL3MBTL1 | |
| SCHEMBL9002496 | 0.81 | MEN1 (0.56) | MAPTNPC1MAPK1HTTL3MBTL1 | |
| SCHEMBL11291087 | 0.81 | MAPT (0.48) | MAPTNPC1MAPK1HTTTDP1 | |
| SCHEMBL1821621 | 0.80 | NR4A1 (0.62) | TDP1CES2CES1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934940-A1 | CYTOKINE PRODUCTION INHIBITORS, TRIAZEPINE COMPOUNDS, AND INTERMEDIATES THEREOF | Japan Tobacco Inc. (JP) | 1999-08-11 | — | — | EP | disclosed |