Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | FER | P16591 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030434 | 0.72 | — | — | |
| SCHEMBL7623449 | 0.68 | — | — | |
| SCHEMBL10900576 | 0.65 | MAOA (0.36) | NPC1RAB9ASMN1; SMN2MAOAMAOB | |
| SCHEMBL10679874 | 0.65 | LRRK2 (0.42) | SMN1; SMN2MAOAMAOBPDGFRAFER | |
| SCHEMBL8880019 | 0.65 | KDM4E (0.32) | — | |
| SCHEMBL28829617 | 0.64 | MAOA (0.36) | NPC1RAB9ASMN1; SMN2MAOAMAOB | |
| SCHEMBL8879355 | 0.63 | PKM (0.33) | — | |
| SCHEMBL1501865 | 0.62 | CDC25B (0.41) | NPC1TP53RAB9AMAPK10SMN1; SMN2 | |
| SCHEMBL5494021 | 0.62 | CDC25B (0.41) | NPC1TP53RAB9AMAPK10SMN1; SMN2 | |
| SCHEMBL168935 | 0.62 | PDGFRA (0.52) | RAB9ASMN1; SMN2MAOAMAOBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044989-A1 | 5-Subsituted 5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-ones, process for preparing them and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-02-03 | — | — | EP | disclosed |