Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 9/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129269 | 0.90 | IGF1R (0.48) | IGF1RTNK2 | |
| SCHEMBL1129455 | 0.83 | IGF1R (0.37) | IGF1RTNK2 | |
| SCHEMBL593640 | 0.76 | TNK2 (0.41) | IGF1RTNK2PIK3CAPIK3CBMTOR | |
| SCHEMBL593638 | 0.76 | TNK2 (0.41) | IGF1RTNK2PIK3CAPIK3CBMTOR | |
| SCHEMBL594301 | 0.75 | GRIN2B (0.49) | IGF1RTNK2 | |
| SCHEMBL1129225 | 0.74 | TNK2 (0.62) | IGF1RTNK2 | |
| SCHEMBL27671106 | 0.73 | SRR (0.44) | — | |
| SCHEMBL1552357 | 0.71 | IGF1R (0.43) | IGF1RTNK2PIK3CAPIK3CBMTOR | |
| SCHEMBL1552360 | 0.71 | IGF1R (0.43) | IGF1RTNK2PIK3CAPIK3CBMTOR | |
| SCHEMBL400470 | 0.71 | TNK2 (0.46) | IGF1RTNK2PIK3CAPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |