Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129220 | 0.83 | IGF1R (0.41) | IGF1RTNK2 | |
| SCHEMBL2327637 | 0.81 | CNR2 (0.40) | IGF1RPDE1CCNR2HTTPDE1A | |
| SCHEMBL1129269 | 0.77 | IGF1R (0.48) | IGF1RTNK2 | |
| SCHEMBL27671106 | 0.75 | SRR (0.44) | HDAC8 | |
| SCHEMBL593236 | 0.74 | SMN1; SMN2 (0.50) | HTT | |
| SCHEMBL593254 | 0.74 | PDE1C (0.38) | IGF1RPDE1CHTTPDE1APDE1B | |
| SCHEMBL593256 | 0.74 | PDE1C (0.38) | IGF1RPDE1CHTTPDE1APDE1B | |
| SCHEMBL1129460 | 0.73 | TNK2 (0.57) | IGF1RTNK2 | |
| SCHEMBL16748877 | 0.73 | PDE1C (0.44) | PDE1CPDE1APDE1BTNK2 | |
| SCHEMBL25277153 | 0.72 | PIK3CA (0.42) | IGF1RPDE1CPDE1APDE1BTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |