Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732982 | 0.86 | ALDH1A1 (0.45) | NPSR1KDM4EMAPTHPGDPOLB | |
| SCHEMBL2241014 | 0.86 | NPSR1 (0.41) | NPSR1KDM4EMAPTHPGDPOLB | |
| SCHEMBL1129051 | 0.81 | KMT2A (0.40) | NPSR1KDM4EMAPTHPGDPOLB | |
| SCHEMBL10847755 | 0.73 | ALPL (0.35) | NPSR1KDM4EMAPTHPGDPOLB | |
| SCHEMBL2008567 | 0.73 | TYMS (0.49) | KDM4EMAPTHPGDPOLBALDH1A1 | |
| SCHEMBL1747974 | 0.73 | KDM4E (0.42) | KDM4EMAPTHPGDALDH1A1CYP1A2 | |
| SCHEMBL10220066 | 0.72 | ALDH1A1 (0.56) | KDM4EMAPTHPGDALDH1A1CYP1A2 | |
| SCHEMBL1835419 | 0.72 | ALPL (0.51) | KDM4EMAPTHPGDALDH1A1CYP1A2 | |
| SCHEMBL1170649 | 0.72 | KDM4E (0.52) | NPSR1KDM4EHPGDALDH1A1CYP1A2 | |
| SCHEMBL13319134 | 0.72 | IDO1 (0.45) | KDM4EMAPTPOLBCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |