Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.73 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.72 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12526825 | 0.97 | LRRK2 (0.68) | HPGDLRRK2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL1512434 | 0.87 | LRRK2 (0.61) | HPGDLRRK2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL12525213 | 0.86 | POLB (0.62) | HPGDLRRK2ALDH1A1MEN1KMT2A | |
| SCHEMBL15652845 | 0.86 | PKM (0.75) | HPGDLRRK2KMT2AKDM4EPKM | |
| SCHEMBL1512520 | 0.86 | LRRK2 (0.60) | HPGDLRRK2HSD11B1PKM | |
| SCHEMBL17555289 | 0.84 | LRRK2 (0.59) | HPGDLRRK2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL12010063 | 0.84 | LRRK2 (0.70) | HPGDLRRK2HSD11B1PKMTSHR | |
| SCHEMBL2956998 | 0.84 | HPGD (0.62) | HPGDLRRK2HSD11B1ALDH1A1KDM4E | |
| SCHEMBL6280995 | 0.83 | HPGD (0.96) | HPGDLRRK2HSD11B1ALDH1A1MEN1 | |
| SCHEMBL2954121 | 0.83 | HPGD (0.66) | HPGDLRRK2HSD11B1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371319-B2 | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-21 | — | — | US | disclosed |
| US-9371319-B2 | Pyrrolopyridineamino derivatives as MPS1 inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-21 | — | — | US | disclosed |
| EP-2686318-B1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | CANCER REC TECH LTD (GB) | 2016-03-09 | — | — | EP | disclosed |
| EP-2686318-B1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | CANCER REC TECH LTD (GB) | 2016-03-09 | — | — | EP | disclosed |
| EP-2665724-A1 | BICYCLIC INHIBITORS OF ALK | AbbVie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012123745-A1 | PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-09-20 | — | — | WO | disclosed |
| WO-2012097682-A1 | BICYCLIC INHIBITORS OF ALK | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |