Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11294741 | 0.81 | TUBB4A (0.49) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL11301753 | 0.80 | GABRP (0.43) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL12500156 | 0.78 | NPC1 (0.57) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL20773666 | 0.77 | NPC1 (0.42) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL10665321 | 0.77 | NPSR1 (0.50) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL7311312 | 0.77 | CA12 (0.47) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL1266209 | 0.75 | KDM4E (0.54) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL2027363 | 0.75 | PDCD1 (0.52) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL334079 | 0.75 | EGFR (0.50) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL29942878 | 0.75 | KDM4E (0.54) | MAPTNPC1RAB9ASMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487486-B2 | Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160052886-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | UNIVERSITY OF MARYLAND, BALTIMORE | 2016-02-25 | — | — | US | disclosed |
| US-9260394-B2 | Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-02-16 | — | — | US | disclosed |
| US-20130289081-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | UNIVERSITA' DEGLI DI PARMA (IT) | 2013-10-31 | — | — | US | disclosed |
| WO-2012097869-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3,4-DIOXYGENASE | UNIVERSITA' DEGLI STUDI DI PARMA (IT) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052886-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | HAAO, NQO2, HAO1 | MAPT 866/4885NPC1 2671/4885RAB9A 1380/4885 |
| US-20130289081-A1 | DERIVATIVES OF NICOTINIC ACID N-OXIDE, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF ENZYME 3-HYDROXYANTHRANILATE-3, 4-DIOXYGENASE | HAAO, NQO2, HAO1 | MAPT 866/4885NPC1 2671/4885RAB9A 1380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.