Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CCR1 | P32246 | 3/20 | 0.47 |
| ▸ | CCR5 | P51681 | 3/20 | 0.47 |
| ▸ | CCR8 | P51685 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593197 | 0.82 | PIN1 (0.56) | PIN1BTKKDM4ELMNACCR1 | |
| SCHEMBL30040683 | 0.82 | PIN1 (0.56) | PIN1BTKKDM4ELMNACCR1 | |
| SCHEMBL23202619 | 0.80 | PIN1 (0.54) | PIN1BTKPRMT5WDR77KDM4E | |
| SCHEMBL31096555 | 0.80 | PIN1 (0.54) | PIN1BTKPRMT5WDR77KDM4E | |
| SCHEMBL27598057 | 0.79 | PIN1 (0.56) | PIN1BTKPRMT5WDR77KDM4E | |
| SCHEMBL1392639 | 0.77 | ADORA3 (0.56) | KDM4ECYP1A2POLBPDE2APDE3B | |
| SCHEMBL4855164 | 0.76 | PIN1 (0.66) | PIN1BTKPRMT5WDR77KDM4E | |
| SCHEMBL11245576 | 0.75 | PRMT5 (0.49) | PRMT5WDR77KDM4ELMNACYP1A2 | |
| SCHEMBL1528433 | 0.73 | PIN1 (0.57) | PIN1BTKKDM4ELMNACCR1 | |
| SCHEMBL9598073 | 0.73 | BTK (0.50) | PIN1BTKPRMT5WDR77KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346221-A | Preparation of 4-amino-6-(pyridinyl)-3(2H)-pyridazinones from 6-(pyridinyl)-3(2H)-pyridazinones | STERLING DRUG INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4305943-A | 4-Amino-6-(pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-12-15 | — | — | US | disclosed |