Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11308676 | 1.00 | ALDH1A1 (0.72) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL13039630 | 0.90 | ALDH1A1 (0.88) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL1285622 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL27727862 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL27525601 | 0.84 | ALDH1A1 (0.72) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL1285623 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL3439644 | 0.83 | HAO1 (0.84) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL316674 | 0.83 | HAO1 (0.84) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL6748868 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HAO1MAPTLMNAHDAC3 | |
| SCHEMBL574953 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HAO1MAPTLMNAHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043141-A1 | Pharmaceutical compositions having antiviral activity for topical administration and the use of 1-(substituted phenyl)-5-(4-morpholinyl)-1-penten-3-one compounds for the preparation of pharmaceutical compositions having an antiviral effect | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| EP-0043141-A1 | Pharmaceutical compositions having antiviral activity for topical administration and the use of 1-(substituted phenyl)-5-(4-morpholinyl)-1-penten-3-one compounds for the preparation of pharmaceutical compositions having an antiviral effect | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| US-4288456-A | Compositions containing 1-aryl-5-(2-propenylamino)-1-penten-3-ones and method for treating inflammatory conditions | E. R. SQUIBB & SONS, INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4173649-A | ANTIULCER AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1979-11-06 | — | — | US | disclosed |