Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 11/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288699 | 0.86 | TAAR1 (0.46) | TAAR1HTR1AALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL13372830 | 0.82 | TAAR1 (0.80) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11290757 | 0.82 | TBXAS1 (0.48) | TAAR1HTR1AALOX15 | |
| SCHEMBL11295562 | 0.79 | TAAR1 (0.69) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL31414967 | 0.79 | TAAR1 (0.75) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11290384 | 0.78 | TAAR1 (0.67) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10719843 | 0.77 | TAAR1 (0.66) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10697156 | 0.77 | TAAR1 (0.56) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL954941 | 0.76 | TAAR1 (0.54) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL27582729 | 0.76 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003732-A2 | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-09-05 | — | — | EP | claimed |
| EP-0064820-A1 | Substituted imidazole and imidazoline derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1982-11-17 | — | — | EP | disclosed |