Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11716424 | 0.89 | PTGS2 (0.62) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| Zomepirac SCHEMBL11495798 | 0.87 | PTGS2 (1.00) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| SCHEMBL11712561 | 0.87 | PTGS2 (0.60) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| Zomepirac SCHEMBL25735 | 0.87 | PTGS2 (1.00) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| SCHEMBL11720805 | 0.87 | PTGS2 (0.60) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| Zomepirac SCHEMBL9655800 | 0.86 | PTGS2 (0.97) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| SCHEMBL7681228 | 0.86 | PTGS2 (0.74) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| Zomepirac SCHEMBL28350948 | 0.86 | PTGS2 (0.97) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| SCHEMBL11717066 | 0.86 | PTGS2 (0.74) | PTGS2ABCB11CYP1A2ALDH1A1LMNA | |
| Zomepirac SCHEMBL43061 | 0.86 | PTGS2 (0.97) | PTGS2ABCB11CYP1A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006845-B1 | PHARMACEUTICAL COMPOSITION COMPRISING A 5-AROYL-1-C1-5 ALKYL-PYRROLE-2-ACETIC ACID COMPOUND AND ACETAMINOPHEN OR ACETYLSALICYLIC ACID | McNeilab, Inc. (US) | 1982-02-03 | — | — | EP | disclosed |
| US-4132788-A | 5-AROYL-1-LOWERALKYL-PYRROLE-2-ACETIC ACID DERIVATIVES, ASPIRIN OR ACETAMINOPHEN | MCNEIL LABORATORIES, INC. (US) | 1979-01-02 | — | — | US | disclosed |
| US-4048191-A | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-13 | — | — | US | disclosed |