Zomepirac

Zomepirac

SCHEMBL25735

Cc1cc(CC(=O)O)n(C)c1C(=O)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 5/20 1.00
ABCB11 O95342 2/20 1.00
CYP1A2 P05177 3/20 0.74
LMNA P02545 2/20 0.74
ALDH1A1 P00352 1/20 0.74
TSHR P16473 1/20 0.74
SMN1; SMN2 Q16637 1/20 0.74
TDP1 Q9NUW8 1/20 0.74
MAPT P10636 4/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C9 P11712 2/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
CYP2C19 P33261 1/20 0.48
PTGS1 P23219 4/20 0.48
CXCL8 P10145 2/20 0.48
AKR1B1 P15121 2/20 0.48
GLO1 Q04760 2/20 0.48
HPGD P15428 1/20 0.43
AKR1C3 P42330 3/20 0.41
AKR1C2 P52895 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zomepirac SCHEMBL11495798 1.00 PTGS2 (1.00) PTGS2ABCB11CYP1A2LMNAALDH1A1
Zomepirac SCHEMBL28350948 0.99 PTGS2 (0.97) PTGS2ABCB11CYP1A2LMNAALDH1A1
Zomepirac SCHEMBL43061 0.99 PTGS2 (0.97) PTGS2ABCB11CYP1A2LMNAALDH1A1
Zomepirac SCHEMBL9655800 0.99 PTGS2 (0.97) PTGS2ABCB11CYP1A2LMNAALDH1A1
Zomepirac SCHEMBL7204056 0.97 PTGS2 (0.95) PTGS2ABCB11CYP1A2LMNAALDH1A1
SCHEMBL12608966 0.89 PTGS2 (0.80) PTGS2ABCB11CYP1A2LMNAALDH1A1
SCHEMBL10905829 0.89 PTGS2 (0.80) PTGS2ABCB11CYP1A2LMNAALDH1A1
SCHEMBL6343780 0.89 PTGS2 (0.80) PTGS2ABCB11CYP1A2LMNAALDH1A1
Zomepirac SCHEMBL8830936 0.89 PTGS2 (0.78) PTGS2ABCB11CYP1A2LMNAALDH1A1
SCHEMBL10943158 0.88 ABCB11 (0.78) PTGS2ABCB11CYP1A2LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 20477 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260130928-A1 COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN ASCENTAWITS PHARMACEUTICALS LTD (CN) 2026-05-14 US claimed
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-4628080-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Jeil Pharmaceutical Co., Ltd. (KR) 2025-10-08 EP claimed
EP-3917907-B1 MODULATORS OF POTASSIUM ION CHANNELS AND USES THEREOF UNIV DEGLI STUDI DI SALERNO (IT) 2025-05-21 EP claimed
CN-119744178-A Combination of AKR1C 3-activated anticancer prodrug compounds and analgesic drugs for the treatment of cancer patients with pain 深圳艾欣达伟医药科技有限公司 2025-04-01 CN claimed
EP-3441087-B1 METHODS OF TREATING CHRONIC PAIN TEVA PHARMACEUTICALS INT GMBH (CH) 2025-02-19 EP claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 US claimed
US-12161726-B2 Biomimetic vesicles and uses thereof OHIO STATE INNOVATION FOUNDATION (US) 2024-12-10 US claimed
EP-4470565-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT OnQuality Pharmaceuticals China Ltd. (CN) 2024-12-04 EP claimed
CN-112770764-B Methods of treating infections using bacteria 因达普特斯治疗有限公司 2024-12-03 CN claimed
US-4344929-A Method of delivering drug with aid of effervescent activity generated in environment of use ALZA CORPORATION (US) 1982-08-17 US claimed
US-4338324-A COMBINATION OF ZOMEPIRAC AND BUTORPHANOL MCNEILAB, INC. (US) 1982-07-06 US claimed
US-4322427-A Analgetic compositions and methods of use BRISTOL-MYERS COMPANY (US) 1982-03-30 US claimed
EP-0006845-B1 PHARMACEUTICAL COMPOSITION COMPRISING A 5-AROYL-1-C1-5 ALKYL-PYRROLE-2-ACETIC ACID COMPOUND AND ACETAMINOPHEN OR ACETYLSALICYLIC ACID McNeilab, Inc. (US) 1982-02-03 EP claimed
US-4299770-A Recovery of substituted pyrrole acetate MALLINCKRODT, INC. (US) 1981-11-10 US claimed
EP-0036145-A1 An orally administered drug form comprising a polar bioactive agent and an adjuvant INTERx RESEARCH CORPORATION (US) 1981-09-23 EP claimed
EP-0031561-A2 A rectally administered suppository comprising a drug and an adjuvant MERCK & CO. INC. (US) 1981-07-08 EP claimed
EP-0027991-A1 Use of combination of compounds for alleviating pain E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-05-06 EP claimed
US-4260629-A Treating pain with acetaminophen and 1,4-dimethyl-5-p-chlorobenzoyl-pyrrole-2-acetic acid E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-04-07 US claimed
US-4132788-A 5-AROYL-1-LOWERALKYL-PYRROLE-2-ACETIC ACID DERIVATIVES, ASPIRIN OR ACETAMINOPHEN MCNEIL LABORATORIES, INC. (US) 1979-01-02 US claimed