Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.59 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | FABP3 | P05413 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226989 | 0.90 | ALDH1A1 (0.59) | FABP4FABP5ALDH1A1KDM4EFABP3 | |
| SCHEMBL5659862 | 0.82 | CA12 (0.50) | ALDH1A1CA12BRD4BRPF1CA9 | |
| SCHEMBL4304286 | 0.80 | APEX1 (0.59) | ALDH1A1KDM4ECA12BRD4BRPF1 | |
| SCHEMBL6198418 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4ECA12BRD4BRPF1 | |
| SCHEMBL4101677 | 0.79 | CA12 (0.50) | ALDH1A1CA12BRD4BRPF1CA9 | |
| SCHEMBL4095757 | 0.79 | CA12 (0.50) | ALDH1A1CA12BRD4BRPF1CA9 | |
| SCHEMBL585623 | 0.78 | CA12 (0.53) | ALDH1A1KDM4ECA12BRD4BRPF1 | |
| SCHEMBL1037171 | 0.78 | CA12 (0.49) | FABP4FABP5ALDH1A1CA12BRD4 | |
| SCHEMBL9111783 | 0.78 | CA12 (0.49) | ALDH1A1CA12BRD4BRPF1CA9 | |
| SCHEMBL4532625 | 0.78 | CA12 (0.53) | ALDH1A1KDM4ECA12BRD4BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0017477-B1 | SPIRO-QUINOLONE HYDANTOINS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | PFIZER INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| EP-0017477-A1 | Spiro-quinolone hydantoins, pharmaceutical compositions containing them, and processes for their preparation | PFIZER INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4193996-A | ALDOSE REDUCTASE INHIBITORS, THERAPEUTICS FOR DIABETES COMPLICATIONS | PFIZER INC. (US) | 1980-03-18 | — | — | US | disclosed |