Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | FABP4 | P15090 | 2/20 | 0.57 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.57 |
| ▸ | FABP3 | P05413 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 2/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296052 | 0.90 | FABP4 (0.59) | ALDH1A1FABP4FABP5FABP3KDM4E | |
| SCHEMBL4304286 | 0.83 | APEX1 (0.59) | ALDH1A1KDM4EAPEX1L3MBTL1KMT2A | |
| SCHEMBL585623 | 0.81 | CA12 (0.53) | ALDH1A1KDM4EMAPTLMNAKMT2A | |
| SCHEMBL3410183 | 0.80 | KMO (0.56) | ALDH1A1FABP4FABP5FABP3KDM4E | |
| SCHEMBL3218538 | 0.80 | KDM4E (0.46) | ALDH1A1FABP4FABP5FABP3KDM4E | |
| SCHEMBL3229548 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4ECA12BRD4BRPF1 | |
| SCHEMBL5659862 | 0.78 | CA12 (0.50) | ALDH1A1KMT2ACA12BRD4BRPF1 | |
| SCHEMBL29941844 | 0.77 | CA12 (0.58) | ALDH1A1KDM4EHTTL3MBTL1MAPT | |
| SCHEMBL1807117 | 0.77 | CA12 (0.53) | ALDH1A1MAPTLMNAKMT2ACA12 | |
| SCHEMBL1052103 | 0.77 | CA12 (0.58) | ALDH1A1KDM4EHTTL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056502-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-03-04 | — | — | US | disclosed |
| EP-0017477-B1 | SPIRO-QUINOLONE HYDANTOINS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | PFIZER INC. (US) | 1982-01-06 | — | — | EP | disclosed |
| EP-0017477-A1 | Spiro-quinolone hydantoins, pharmaceutical compositions containing them, and processes for their preparation | PFIZER INC. (US) | 1980-10-15 | — | — | EP | disclosed |
| US-4193996-A | ALDOSE REDUCTASE INHIBITORS, THERAPEUTICS FOR DIABETES COMPLICATIONS | PFIZER INC. (US) | 1980-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056502-A1 | COMPOUNDS | NRDC, NACA, NAA50 | ALDH1A1 4233/4885FABP4 3771/4885FABP5 2942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.