Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | PLD2 | O14939 | 7/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 7/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11304432 | 0.88 | HDAC6 (0.40) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL11297379 | 0.88 | HDAC1 (0.42) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL11299454 | 0.83 | HDAC1 (0.44) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL11294915 | 0.81 | HDAC6 (0.50) | HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL11298764 | 0.80 | HDAC1 (0.46) | HDAC6HDAC1HDAC8 | |
| SCHEMBL11294786 | 0.76 | HDAC6 (0.46) | HDAC6HDAC1HDAC3HDAC2L3MBTL1 | |
| SCHEMBL11302647 | 0.70 | HDAC6 (0.43) | HDAC6HDAC1KDM1AHDAC8 | |
| SCHEMBL16175428 | 0.63 | HDAC1 (0.42) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL18153909 | 0.63 | ADRA1A (0.33) | HDAC6HDAC8 | |
| SCHEMBL30986828 | 0.62 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |