Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299454 | 0.90 | HDAC1 (0.44) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11304432 | 0.89 | HDAC6 (0.40) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11296090 | 0.88 | HDAC6 (0.41) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11298764 | 0.84 | HDAC1 (0.46) | HDAC1HDAC6HDAC8 | |
| SCHEMBL11294915 | 0.83 | HDAC6 (0.50) | HDAC1HDAC6HDAC8HDAC2ALOX15 | |
| SCHEMBL11294786 | 0.80 | HDAC6 (0.46) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL16175428 | 0.73 | HDAC1 (0.42) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11298725 | 0.69 | HDAC1 (0.38) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11297190 | 0.65 | HDAC6 (0.44) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL11306334 | 0.63 | HDAC1 (0.45) | HDAC1HDAC6HDAC8HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |